Alprostadil (Prostaglandin E1) is a lipid-based eicosanoid derived from arachidonic acid metabolism and is widely utilized in research focused on vasodilation, smooth muscle relaxation, and microvascular regulation. As a naturally occurring prostaglandin, Alprostadil serves as a potent mediator of local blood flow and is essential in the study of cardiovascular physiology and urogenital signaling.

With a molecular weight of 354.49 g/mol and high lipophilicity, Alprostadil interacts with prostaglandin E (EP) receptors on vascular smooth muscle, where it initiates signaling cascades through activation of adenylate cyclase. This increases intracellular cAMP levels, promoting downstream relaxation of vascular and non-vascular smooth muscle. These mechanisms make it a primary agent in in vitro models investigating penile vasculature, ductus arteriosus patency, and peripheral circulation under stress or ischemic conditions. Due to its high bioactivity and low threshold for physiological response, Alprostadil is typically applied at microgram concentrations in precision-based assays.

Researchers value Alprostadil for its consistent pharmacodynamic profile and ability to elicit dose-dependent responses, especially in organ bath preparations, vascular ring models, and receptor-ligand interaction studies. Its formulation is optimized for experimental reproducibility and stability under laboratory conditions.

Format: Lyophilized powder
Purity: ≥99% (HPLC Verified)
Molecular Formula: C20H34O5
Storage Recommendations: Store at -20°C in a desiccated environment; reconstituted solutions should be used immediately or aliquoted and frozen
Intended Research Use: Studies in vascular tone regulation, endothelial function, erectile physiology, smooth muscle pharmacology, and cAMP-mediated signal transduction
For Research Use Only. Not for human consumption.