Adipotide is a synthetic peptidomimetic agent designed to selectively target the vasculature of white adipose tissue, offering a unique approach for studying programmed cell death in adipocyte-associated endothelial cells. It has become a focal point in preclinical models investigating adipose tissue modulation, vascular targeting strategies, and obesity-related metabolic mechanisms.

The structure of Adipotide comprises a targeting domain that binds to prohibitin—a mitochondrial membrane protein expressed on adipose vascular endothelium—linked to a pro-apoptotic sequence derived from the BH3-only class of Bcl-2 family proteins. This dual-component design facilitates receptor-specific uptake followed by mitochondrial-mediated apoptosis in targeted cells. In research models, Adipotide has been shown to reduce white adipose mass without affecting brown fat or muscle tissue, making it a compelling candidate in studies focused on selective tissue ablation and angiogenesis inhibition.

Formulated at ≥98% purity, Adipotide is stable in its lyophilized form under standard laboratory storage conditions. It is compatible with both in vitro and in vivo research applications when handled under appropriate biosafety protocols. Its targeted mode of action supports investigations into vascular remodeling, adipokine signaling, and tissue-specific peptide delivery systems.

Format: Lyophilized powder
Purity: ≥98% (HPLC Verified)
Molecular Formula: C60H91N13O13S
Storage Recommendations: Store at -20°C; reconstituted aliquots should be protected from light and used within validated stability windows
Intended Research Use: Studies on targeted adipose tissue modulation, vascular apoptosis mechanisms, angiogenesis disruption, and peptide-guided delivery research
For Research Use Only. Not for human consumption.