5-Amino-1MQ is a potent and selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in the methylation of nicotinamide and regulation of intracellular NAD⁺ levels. It has become a molecule of significant interest in research exploring the biochemical control of energy metabolism, cellular longevity, and metabolic stress responses.

5-Amino-1MQ is a small-molecule analog derived from 1-methylquinolinium compounds, offering a low molecular weight of 174.22 g/mol and excellent solubility for biochemical assay systems. While not classified as a peptide, it is commonly used in conjunction with peptide research due to its overlapping relevance in studies involving mitochondrial regulation, sirtuin activation, and adipose tissue remodeling. Experimental data from in vitro and ex vivo models indicate that 5-Amino-1MQ may modulate pathways linked to caloric restriction mimetics and oxidative metabolism through its suppression of NNMT expression. This activity has made it a valuable tool in investigations into cellular aging, NAD⁺ salvage pathways, and energy expenditure.

Format: Lyophilized powder
Purity: ≥98% (HPLC Verified)
Molecular Formula: C10H12N2O
Storage Recommendations: Store at -20°C in a dry, dark environment; reconstituted material should be aliquoted and used within standard stability timeframes
Intended Research Use: Studies on NNMT inhibition, sirtuin and NAD⁺ metabolism, mitochondrial bioenergetics, and adipose signaling mechanisms
For Research Use Only. Not for human consumption.